FORMULASI DAN UJI AKTIVITAS SEDIAAN GEL ANTI JERAWAT EKSTRAK ETANOL DAUN NILAM ( Pogostemon cablin ( Blanco. ) TERHADAP BAKTERI Proplonibacterium acnes.

Abstract

Currently topical anti-acne drugs have been widely used in the form of gels and creams, but not many topical anti-acne contained herbal, are commercially avaible acne is a common skin disease that occurs beginning with increased production before aggravated bacterial attacks. One of the plants is likely to have active ingredients or agents can potentially prevent and treat acne is patchouli leaves (Pogostemoncablin (Blanco.) Benth) with its anti-bacterial properties. Because the use directly on the body is less favored by the public, it is made in the form of preparations so that its use is more practical and comfortable, for example in the form of gels aim to develop a stable formulation of ethanol extract gel preparations from natural ingredients.Fresh patchouli leaves were made into simplicia and extracted using ethanol 80% phytochemical screening performed against fresh patchouli leaves and extracts. The preparation formulation of the gel used patchouli leaf ethanol extract concentrations of 15%, 20% and 25%. Dosage evaluation includes physical quality test of preparation, hedonic test, irritation test, pH test, spread power test, viscosity test, emulsion type test and antibacterial activity against Propionibacterium acnes by diffusion to use punch hole. The results showed that the compound of fresh patchouli leaves, and patchouli leaf ethanol extract contained alkaloids, flavonoids, saponins, tannins, glycosides and steroids/triterpenoids. Patchouli leaf ethanol extract can be formulated into gel preparations, has a distinctive aroma, homogeneous, pH 5.5 – 5.9, with a spread power of 6 cm – 8.3 cm, with a type of oil emulsion in water, with a viscosity of 2930 - 18930 stable in storage for 8 weeks and the panelist's preferred formula is a concentration of 25%. Strong category antibacterial activity at 25% concentration preparation with a diameter of 15.66 mm.